Victoria Martin, PhD
I completed my PhD, entitled “Changes in human B cell repertoire with Age”, in 2014 with Deborah Dunn-Walters in the Department of Immunobiology. A diverse B cell repertoire is vital for generating sufficient protection against invading pathogens. We showed that a decrease in the BCR repertoire and a skewing of B cell populations occurs with increasing age and may be responsible for the diminished immune protection in older people. I am now undertaking my post-doc which aims to extend this work by continuing phenotypic B cell analysis (by Mass Cytometry) and investigating age-related changes in repertoire in a primary immune response (yellow fever vaccine) using high throughput sequencing. The project is part of a systems immunology multiscale analysis programme, bringing together biology, mathematics to increase systems immunology expertise.
Joselli Silva O’Hare, PhD
Joselli Silva completed her PhD in Human and Experimental Pathology in February 2014 at the Federal University of Bahia (Brazil). In 2012, she spent one year in the Dunn-Walters Lab working on B cell repertoire in humans, with particular reference to changes with age and disease, as part of her Sandwich PhD. During this period she learned advanced molecular biology techniques and worked in different projects with high throughput sequencing of the heavy and light chain repertoire of human B cell, isolation of heavy and light chain pairs from single cells and cloning/expression of the antibody.In May 2014, she joined Dunn-Walters Lab where she is currently a post-doctoral researcher working on the MABRA: Multiscale Analysis of B cell Responses in ageing project, funded by the MRC and BBSRC.
Tihomir Dodev, PhD
Tihomir completed his PhD in Molecular Biology at the Randall Division of Cell and Molecular Biophysics at KCL, where he developed a versatile antibody cloning and expression system for the discovery and characterisation of novel antibodies against melanoma.
He joined the Dunn-Walters lab in September 2013 on a Dunhill Medical Trust funded project to study B cell antibody repertoire development in older people. His work uses high throughput sequencing data analysis of the B cell antibody repertoire to define age-related changes in Immunoglobulin (Ig) gene usage. Ig genes that are more, or less, prevalent with ageing can be cloned and expressed to investigate their specificity.
Alexander Mozeika, PhD
Alexander Mozeika received a MSc in Information Processing and Neural Networks in 2005 and a PhD in Applied Mathematics in 2009 from King’s
From 2009 - 2012 and from 2012 - 2014 he was a post-doctoral researcher with the Non- linearity and Complexity Research Group at Aston University and with the Department of Information and Computer Science at Aalto University respectively.
He is currently a post-doctoral researcher with the Institute for Mathematical and Molecular Biomedicine at King’s College London working on the MABRA project. . His research interests are in information theory, statistical inference and statistical physics.
After completing my BSc in Biology with a Year in Industry/Research at Imperial College London, I began my PhD in the Dunn-Walters lab in October 2014. I am funded by a BBSRC-CASE studentship in collaboration with MedImmune.
During B cell development, B cells that produce autoreactive antibodies are removed from the repertoire at the central tolerance checkpoint to prevent autoimmune
disease. The aim of my PhD is to identify genetic and structural characteristics of autoreactive and self-tolerant antibodies with the hope that this information will be useful in the identification of antibodies for therapeutic purposes.
Faculty of Health and Medical Sciences, Duke of Kent Building, University of Surrey,
Guildford, GU2 7XH