Tumour Infiltrating B cells in Breast Cancer
It is difficult for the immune system to recognise cancer as a cancer is made from our own cells that have grown out of control, and the immune system is normally trained NOT to recognise self. Some tumours have cells from the immune system inside them. Some of these immune cells in a tumour might be regulatory cells that suppress the immune response because they think it is normal self. However, in some tumours we think that the immune cells are mostly there to fight the disease, and there are reports that the presence of B cells in breast tumours is correlated with improved prognosis.
We plan to use our novel molecular methods of studying the B cell repertoire to investigate what type of B cells are in breast tumours and clone antibodies from the tumours to see if they can be used in treatment and diagnostics.
Faculty of Health and Medical Sciences, Duke of Kent Building, University of Surrey,
Guildford, GU2 7XH